Which of the following best defines a Schedule II medication?

A Schedule II medication is defined as having accepted medical use while possessing a high potential for abuse. This classification indicates that these substances can lead to severe psychological or physical dependence when misused. Examples include medications like opioids (such as morphine or oxycodone) and stimulants (like amphetamines), which are effective for certain medical conditions but can be easily misused due to their psychoactive effects.

The other choices do not accurately represent Schedule II medications. For instance, the definition implying no accepted medical use corresponds to substances placed in Schedule I. A classification reflecting low potential for abuse would align with medications found in lower schedules, such as Schedule V, where less stringent controls apply. Finally, stating accepted medical use with limited dependence does not accurately capture the significant risk of dependence associated with Schedule II drugs. Thus, the correct characterization is that these medications have recognized therapeutic uses alongside a high likelihood of abuse.